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Industrial-scale fermentation

Demo · Reference case study

🧫 Industrial-scale fermentation

To showcase what STAMM does on a realistic industrial process, we use a 100,000 L fed-batch fermentation for the production of penicillin by Penicillium chrysogenum as the reference case study. Data come from the open IndPenSim benchmark.

100,000 L
Production vessel (radius 2.1 m)
3
Rushton impellers @ 100 rpm
Fed-batch
Penicillin fermentation
IndPenSim
Open benchmark dataset
Schematic of the industrial penicillin fed-batch bioreactor used in the STAMM demo

FIG · Schematic of the 100,000 L fed-batch penicillin bioreactor and its main inputs/outputs. Adapted from Goldrick et al., 2015, Journal of Biotechnology, 193, 70–82, and Metcalfe et al., 2025, Computers & Chemical Engineering.

Why this case study​

This type of large-scale fed-batch fermentation is representative of real industrial biotechnology operations, where process dynamics are nonlinear, measurements are noisy or delayed, and supervisory control must be combined with advanced monitoring and optimization strategies. It's the kind of setting where soft sensors actually earn their keep — and where STAMM's monitoring and maintenance layer matters.

The data originate from the Industrial Penicillin Simulation dataset (IndPenSim) — a first-principles benchmark model and open dataset that replicates an industrial penicillin campaign in silico, capturing the dynamics, noise, and operating regimes you'd encounter on a real plant.